THE SIGNIFICANCE OF POLYMORPHIC VARIANTS A66G OF THE MTRR GENE, A2756G OF THE MTR GENE, C677T AND A1298T OF THE MTHFR GENE IN PATIENTS WITH PSORIASIS
Keywords:
Psoriasis, psoriatic arthritis, genesAbstract
In world literature wide presented results research associations genes one-carbon metabolism And their function onally significant allelic options With multitude pathologies. MTHFR ( m e - tylenetetrahydrofolate reductase ) plays key role V metabolism folic acids. The most studied SNPs of the MTHFR gene (OMIM 607093) are o- nonucleotide polymorphisms C677T and A1298C. Homozygotes for polymorphic allele T V positions 677 gene MTHFR celebrated thermolability enzyme And decrease his activities to 70% from average values, allele WITH V positions 1298 V homozygous condition reduces activity MTHFR to 60%, What leads To disruption of folate metabolism and methylation processes in the cell, hyper - homocysteinemia . The material for the study was samples of peripheral blood from 56 patients with various forms of psoriasis, registered at the Regional Clinical Dermatovenereology and Venereal Diseases Center - logical dispensary №1 (Kharkov). For polymorphism C677T the reaction amplification was carried out using GenPak MTHFR PCRtest kits ( Isogen , RF). Genotyping of polymorphisms A1298C, A2756G and A66G was conducted by method PCR-RFLP. Carriage of polymorphic alleles according to analyzed one-carbon metabolism genes are predictors for implementation in pathological phenotype « psoriatic genotype".
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