THE ROLE OF FREE RADICAL LIPID OXIDATION IN METABOLIC DISORDERS IN EXPERIMENTAL MYOCARDIAL INFARCTION.
Keywords:
endothelial dysfunction, atherosclerosis, autoimmune processes, hypercholesterolemia, hyperlipoproteinemia.Abstract
The present work is devoted to the study of the role of free radical oxidation of lipids in the development of metabolic disorders in experimental myocardial infarction. The conducted studies have shown that oxidative stress caused by excess free radicals promotes the activation of lipid peroxidation (LPO), disruption of the antioxidant system and destabilization of cell membranes. These processes play a key role in the pathogenesis of ischemic myocardial injury and aggravate metabolic disorders, including lipid metabolism imbalance, inhibition of energy metabolism and the development of secondary structural changes. It was found that the severity of LPO processes directly correlates with the severity of cardiac muscle damage and disorders of systemic homeostasis regulation. The obtained data emphasize the importance of timely antioxidant correction in the complex therapy of myocardial infarction. Thus, free radical oxidation of lipids is considered as one of the key pathogenetic mechanisms of metabolic disorders, which opens up prospects for the development of new directions in the treatment and prevention of cardiac diseases.
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